Across TCGA cell cohorts, SMYD4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMYD4-associated genes across cancer lineages are OR5H6, GOLGA6L6, and RFPL3. Each is linked with SMYD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD4-to-partner and partner-to-SMYD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD4→partner) and Y-score (partner→SMYD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR5H6 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	GOLGA6L6 →	+0.013	+5.369	<.001	.004	3	1
LARGE_INTESTINE	RFPL3 →	+0.029	+2.925	.004	.007	3	1
LARGE_INTESTINE	C1orf94 →	+0.066	+3.297	<.001	.002	3	1
LARGE_INTESTINE	NAA11 →	+0.403	+3.443	<.001	.009	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

SMYD4 survival (RNA) · tumor vs normal (RNA) · all SMYD4 data types