Across TCGA patient cohorts, SMYD3 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,296 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMYD3-associated proteins across cancer lineages are GATAD2B, HNRNPU, and IPO9. Each is linked with SMYD3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMYD3-to-partner and partner-to-SMYD3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD3→partner) and Y-score (partner→SMYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GATAD2B →	+0.396	+0.886	<.001	<.001	3	6
LSCC	HNRNPU →	+0.237	+0.490	<.001	<.001	3	6
LSCC	IPO9 →	+0.356	+0.475	<.001	<.001	3	6
HNSC	PARP1 →	+0.450	+0.669	<.001	<.001	3	6
GBM	UBQLN4 →	+0.212	+0.301	<.001	.001	3	5
HNSC	RCOR3 →	+0.465	+0.855	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,296 associations by consensus.

Exploration

SMYD3 survival (RNA) · tumor vs normal (RNA) · all SMYD3 data types