Across TCGA patient cohorts, SMYD3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMYD3-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and PDCD4. Each is linked with SMYD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD3-to-partner and partner-to-SMYD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD3→partner) and Y-score (partner→SMYD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.508	+2.321	.025	.033	3	2
UCEC	mTOR_pS2448 →	-0.191	-3.571	.002	.002	3	2
UCEC	PDCD4 →	-0.697	-2.906	<.001	.001	3	2
UCEC	Src_pY416 →	-0.246	-2.584	.016	.010	3	2
UCEC	ATM →	-0.702	-3.308	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.113	-2.295	.007	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

SMYD3 survival (RNA) · tumor vs normal (RNA) · all SMYD3 data types