SMYD2

Across TCGA patient cohorts, SMYD2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMYD2-associated genes across cancer lineages are p62 Lck ligand, STAT3_pY705, and Cyclin-B1. Each is linked with SMYD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD2-to-partner and partner-to-SMYD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SMYD2-low versus SMYD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD2→partner) and Y-score (partner→SMYD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.348	+1.594	.007	.042	3	2
UCEC	STAT3_pY705 →	-0.394	-2.690	<.001	.006	3	2
UCEC	Cyclin-B1 →	+0.873	+3.807	<.001	<.001	3	2
UCEC	eIF4E →	+0.219	+3.087	.009	<.001	3	1
UCEC	INPP4B →	-0.327	-3.459	.012	.005	3	1
UCEC	Ku80 →	+0.193	+1.498	.042	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by SMYD2 expression — UCEC

Explore this box plot interactively →