SMYD2

Across TCGA cell cohorts, SMYD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,455 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMYD2-associated GO terms across cancer lineages are Regulation of chromosome segregation, Spindle organization, and Regulation of metaphase/anaphase transition of cell cycle. Each is linked with SMYD2 in more than 12 cancer types. Because this analysis shows association rather than direction, both SMYD2-to-partner and partner-to-SMYD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome segregation grouped by SMYD2-low versus SMYD2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD2→partner) and Y-score (partner→SMYD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.112	+1.000	.003	.006	3	13
BONE	Spindle organization →	+0.087	+0.825	.004	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.116	+1.178	<.001	.002	3	12
BLOOD_Myeloma	Mitotic sister chromatid segregation →	+0.117	+1.366	.001	.009	3	12
BLOOD_Lymphoma	Regulation of mitotic sister chromatid separation →	+0.089	+0.712	.001	.006	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.119	+1.039	<.001	.004	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,455 associations by consensus.

Regulation of chromosome segregation by SMYD2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →