SMYD2

Across TCGA cell cohorts, SMYD2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMYD2-associated genes across cancer lineages are FAM71B, FANCD2OS, and TAFA1. Each is linked with SMYD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD2-to-partner and partner-to-SMYD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71B grouped by SMYD2-low versus SMYD2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD2→partner) and Y-score (partner→SMYD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM71B →	+0.006	+5.662	<.001	.002	3	2
LARGE_INTESTINE	FANCD2OS →	+0.165	+3.667	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	ASIC5 →	+0.227	+3.943	<.001	.002	3	1
LUNG_NSCLC_LUAD	ACSM2B →	+0.042	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FAM71B by SMYD2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →