SMYD1

Across TCGA pan-cancer cohorts, SMYD1 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SMYD1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMYD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SMYD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC are the cancer types where SMYD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	1.000	0.879	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

SMYD1–HNSC (DFS)

Open the HNSC breakdown →