SMYD1

Across TCGA patient cohorts, SMYD1 mutation is significantly associated with the RNA expression of many other genes, with 5,828 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMYD1-associated genes across cancer lineages are BUB1B, PANK4, and CHAF1B. Each is linked with SMYD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMYD1-to-partner and partner-to-SMYD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB1B grouped by SMYD1-low versus SMYD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD1→partner) and Y-score (partner→SMYD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB1B →	+0.894	+2.595	<.001	<.001	3	3
UCEC	PANK4 →	+0.420	+1.765	<.001	<.001	3	3
UCEC	CHAF1B →	+0.735	+1.999	<.001	<.001	3	3
UCEC	NOL9 →	+0.414	+1.808	<.001	<.001	3	3
UCEC	WRN →	+0.556	+3.129	<.001	<.001	3	3
UCEC	OXGR1 →	-0.693	-2.726	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,828 associations by consensus.

BUB1B by SMYD1 expression — UCEC

Explore this box plot interactively →