SMYD1

Across TCGA cell cohorts, SMYD1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SMYD1-associated genes across cancer lineages are TLE7, GH2, and OC90. Each is linked with SMYD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMYD1-to-partner and partner-to-SMYD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE7 grouped by SMYD1-low versus SMYD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMYD1→partner) and Y-score (partner→SMYD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TLE7 →	+0.022	+5.969	<.001	.001	3	2
LUNG_NSCLC_LUAD	GH2 →	+0.043	+3.696	<.001	<.001	3	2
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	2
BLOOD_Myeloma	IL1F10 →	+0.036	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPATA19 →	+0.033	+4.807	<.001	.006	3	1
SOFT_TISSUE	SFTPA1 →	+0.164	+3.999	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TLE7 by SMYD1 expression — BLOOD_Leukemia

Explore this box plot interactively →