SMURF2

Across TCGA patient cohorts, SMURF2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMURF2-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and ASNS. Each is linked with SMURF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMURF2-to-partner and partner-to-SMURF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SMURF2-low versus SMURF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMURF2→partner) and Y-score (partner→SMURF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.655	-2.070	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.232	-2.070	.007	.001	3	2
UCEC	ASNS →	+0.502	+2.807	<.001	.002	3	2
UCEC	FoxM1 →	+0.177	+1.440	.048	.024	3	1
UCEC	FOXO3a_pS318_S321 →	-0.114	-2.160	.008	.003	3	1
UCEC	INPP4B →	-0.326	-2.906	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PDCD4 by SMURF2 expression — UCEC

Explore this box plot interactively →