SMURF2

Across TCGA cell cohorts, SMURF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,077 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SMURF2-associated GO terms across cancer lineages are Positive regulation of cytoskeleton organization, Primary alcohol metabolic process, and Positive regulation of focal adhesion assembly. Each is linked with SMURF2 in more than 14 cancer types. Because this analysis shows association rather than direction, both SMURF2-to-partner and partner-to-SMURF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoskeleton organization grouped by SMURF2-low versus SMURF2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMURF2→partner) and Y-score (partner→SMURF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of cytoskeleton organization →	+0.080	+2.332	.004	<.001	3	15
LIVER	Primary alcohol metabolic process →	-0.142	-1.923	.003	.001	3	15
BONE	Positive regulation of focal adhesion assembly →	+0.209	+1.147	<.001	<.001	3	14
OVARY	Positive regulation of ferroptosis →	+0.172	+1.584	<.001	<.001	3	13
BONE	Positive regulation of cell-substrate junction organization →	+0.173	+1.272	<.001	<.001	3	13
BONE	Regulation of cell-matrix adhesion →	+0.139	+1.047	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,077 associations by consensus.

Positive regulation of cytoskeleton organization by SMURF2 expression — LUNG_NSCLC_LUSC

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