SMURF2

Across TCGA cell cohorts, SMURF2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMURF2-associated genes across cancer lineages are GSC2, DEFA6, and LRIT2. Each is linked with SMURF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMURF2-to-partner and partner-to-SMURF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSC2 grouped by SMURF2-low versus SMURF2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMURF2→partner) and Y-score (partner→SMURF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	GSC2 →	+0.023	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFA6 →	+0.164	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	LRIT2 →	+0.022	+4.887	<.001	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GSC2 by SMURF2 expression — KIDNEY

Explore this box plot interactively →