Across TCGA pan-cancer cohorts, SMURF1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SMURF1 data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMURF1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMURF1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.
HNSC, READ, and UCEC are the cancer types where SMURF1 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.