Across TCGA pan-cancer cohorts, SMURF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SMURF1 data layer compared with 23 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SMURF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SMURF1 expression acts as an unfavorable survival marker.

PDAC, LUAD, and LSCC are the cancer types where SMURF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.565	0.941	<.001	44	view →
LUAD	DFS	Median	All	0.421	0.728	.013	15	view →
LSCC	DFS	Tertile	II,III,IV	0.319	1.000	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SMURF1 tumor-vs-normal RNA expression · all SMURF1 data types