Across TCGA patient cohorts, SMURF1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMURF1-associated genes across cancer lineages are MIG-6, Caspase-7-cleavedD198, and eIF4E. Each is linked with SMURF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMURF1-to-partner and partner-to-SMURF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMURF1→partner) and Y-score (partner→SMURF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIG-6 →	+0.060	+1.138	.045	.022	3	3
UCEC	Caspase-7-cleavedD198 →	+0.721	+2.584	<.001	<.001	3	3
UCEC	eIF4E →	+0.180	+1.754	.004	.001	3	2
UCEC	FoxM1 →	+0.172	+1.530	.027	.004	3	2
UCEC	INPP4B →	-0.307	-2.137	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.143	-2.571	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

SMURF1 survival (RNA) · tumor vs normal (RNA) · all SMURF1 data types