Across TCGA cell cohorts, SMURF1 mutation is significantly associated with the RNA expression of many other genes, with 220 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMURF1-associated genes across cancer lineages are CFHR2, ADAM7, and OR2T12. Each is linked with SMURF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMURF1-to-partner and partner-to-SMURF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMURF1→partner) and Y-score (partner→SMURF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CFHR2 →	+0.060	+5.169	<.001	.004	3	2
BLOOD_Leukemia	ADAM7 →	+0.035	+4.922	<.001	.009	3	2
BREAST	OR2T12 →	+0.019	+5.169	<.001	.005	3	2
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
STOMACH	STATH →	+0.287	+4.129	<.001	.007	3	1
STOMACH	OR4S2 →	+0.015	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

Exploration

SMURF1 survival (RNA) · tumor vs normal (RNA) · all SMURF1 data types