SMU1

Across TCGA pan-cancer cohorts, SMU1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SMU1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SMU1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SMU1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and HNSC are the cancer types where SMU1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.679	0.174	.004	8	view →
LUAD	DFS	Median	All	0.762	0.484	.011	5	view →
HNSC	DFS	Tertile	All	0.357	0.906	.047	4	view →
PDAC	OS	Quartile	III,IV	0.977	0.637	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SMU1–GBM (OS)

Open the GBM breakdown →