SMU1

Across TCGA patient cohorts, SMU1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMU1-associated genes across cancer lineages are 4E-BP1, ER-alpha_pS118, and MEK1. Each is linked with SMU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMU1-to-partner and partner-to-SMU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SMU1-low versus SMU1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMU1→partner) and Y-score (partner→SMU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.290	+3.029	.026	.018	3	2
UCEC	ER-alpha_pS118 →	-0.359	-3.584	.038	.002	3	1
UCEC	MEK1 →	+0.505	+2.321	.004	.034	3	1
UCEC	N-Ras →	-0.118	-2.446	.039	.020	3	1
UCEC	p62 Lck ligand →	+0.545	+3.584	<.001	.002	3	1
UCEC	Cyclin-B1 →	+0.630	+3.584	.020	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

4E-BP1 by SMU1 expression — UCEC

Explore this box plot interactively →