Across TCGA patient cohorts, SMTNL2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,866 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SMTNL2-associated genes across cancer lineages are AKAP12, EDNRB, and PLPP3. Each is linked with SMTNL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMTNL2-to-partner and partner-to-SMTNL2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTNL2→partner) and Y-score (partner→SMTNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKAP12 →	+1.064	+0.852	<.001	<.001	3	3
CCRCC	EDNRB →	+1.133	+0.605	.006	<.001	3	3
CCRCC	PLPP3 →	+0.516	+0.444	<.001	<.001	3	3
CCRCC	EMCN →	+1.124	+0.496	<.001	<.001	3	3
HNSC	PDE2A →	+0.867	+1.345	<.001	<.001	3	3
CCRCC	CISH →	+0.718	+0.402	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,866 associations by consensus.

Exploration

SMTNL2 survival (RNA) · tumor vs normal (RNA) · all SMTNL2 data types