Across TCGA cell cohorts, SMTNL2 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMTNL2-associated genes across cancer lineages are GK2, BMP15, and KRT71. Each is linked with SMTNL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMTNL2-to-partner and partner-to-SMTNL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTNL2→partner) and Y-score (partner→SMTNL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GK2 →	+0.013	+5.754	<.001	.002	3	1
BLOOD_Lymphoma	BMP15 →	+0.017	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	KRT71 →	+0.007	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	FRMD7 →	+0.313	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	C7orf33 →	+1.015	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.101	+4.452	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

SMTNL2 survival (RNA) · tumor vs normal (RNA) · all SMTNL2 data types