Across TCGA patient cohorts, SMTN mutation is significantly associated with the RNA expression of many other genes, with 5,250 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMTN-associated genes across cancer lineages are PPIP5K1, OR1D4, and RPL23AP82. Each is linked with SMTN in more than 3 cancer types. Because this analysis shows association rather than direction, both SMTN-to-partner and partner-to-SMTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTN→partner) and Y-score (partner→SMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPIP5K1 →	+0.492	+3.710	<.001	<.001	3	4
KIRP	OR1D4 →	+0.067	+6.528	<.001	.001	3	3
UCEC	RPL23AP82 →	+0.480	+2.157	<.001	<.001	3	3
UCEC	WDR76 →	+0.930	+2.743	<.001	<.001	3	3
UCEC	CCNB2 →	+0.584	+2.416	<.001	<.001	3	3
UCEC	PDZD8 →	+0.830	+2.425	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,250 associations by consensus.

Exploration

SMTN survival (RNA) · tumor vs normal (RNA) · all SMTN data types