Across TCGA patient cohorts, SMTN mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMTN-associated genes across cancer lineages are ATM, 4E-BP1, and PCNA. Each is linked with SMTN in more than 3 cancer types. Because this analysis shows association rather than direction, both SMTN-to-partner and partner-to-SMTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTN→partner) and Y-score (partner→SMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.393	-2.794	.005	.002	3	4
UCEC	4E-BP1 →	+0.322	+3.029	<.001	<.001	3	3
COAD	PCNA →	+0.259	+2.820	.016	.035	3	2
UCEC	eIF4E →	+0.169	+2.169	.010	.003	3	2
UCEC	MEK1 →	+0.330	+1.999	.004	.002	3	2
COAD	ERK2 →	+0.177	+3.000	.035	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

SMTN survival (RNA) · tumor vs normal (RNA) · all SMTN data types