Across TCGA cell cohorts, SMTN mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMTN-associated genes across cancer lineages are ADAM7, FAM205A, and KRTAP4-1. Each is linked with SMTN in more than 1 cancer types. Because this analysis shows association rather than direction, both SMTN-to-partner and partner-to-SMTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTN→partner) and Y-score (partner→SMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ADAM7 →	+0.006	+3.099	<.001	.002	3	2
LARGE_INTESTINE	FAM205A →	+0.014	+2.444	.003	.008	3	2
BREAST	KRTAP4-1 →	+0.353	+3.758	.001	.007	3	2
BREAST	C1orf146 →	+0.030	+3.963	<.001	.003	3	2
SOFT_TISSUE	SPATA16 →	+0.053	+2.874	<.001	.008	3	1
SOFT_TISSUE	CBY2 →	+0.040	+3.052	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

SMTN survival (RNA) · tumor vs normal (RNA) · all SMTN data types