Across TCGA cell cohorts, SMTN mutation is significantly associated with the mutation status of many other genes, with 5,023 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMTN-associated genes across cancer lineages are PRRC2C, BBX, and KAZN. Each is linked with SMTN in more than 5 cancer types. Because this analysis shows association rather than direction, both SMTN-to-partner and partner-to-SMTN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMTN→partner) and Y-score (partner→SMTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRRC2C →	+4.075	+3.736	<.001	<.001	1	6
LARGE_INTESTINE	BBX →	+3.047	+2.630	.005	.005	1	5
LARGE_INTESTINE	KAZN →	+5.439	+4.222	<.001	<.001	1	4
CNS	PI4KA →	+4.459	+5.277	.005	.005	1	4
CNS	PCDHA10 →	+5.044	+5.614	.003	.003	1	4
CNS	ACACA →	+4.044	+5.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,023 associations by consensus.

Exploration

SMTN survival (RNA) · tumor vs normal (RNA) · all SMTN data types