SMS

Across TCGA pan-cancer cohorts, SMS mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMS data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMS expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

HNSC, UCEC, and GBM are the cancer types where SMS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.166	0.964	.010	36	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.422	.011	16	view →
GBM	OS	Tertile	All	0.272	0.581	.011	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.901	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMS–HNSC (OS)

Open the HNSC breakdown →