SMS

Across TCGA patient cohorts, SMS RNA expression is significantly associated with the protein abundance of many other proteins, with 11,446 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMS-associated proteins across cancer lineages are SMC2, RRM2_S20, and NCAPG. Each is linked with SMS in more than 6 cancer types. Because this analysis shows association rather than direction, both SMS-to-partner and partner-to-SMS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMS versus SMC2 in GBM, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMS→partner) and Y-score (partner→SMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.575	+0.526	.002	.001	3	7
LUAD	RRM2_S20 →	+1.031	+0.366	<.001	.001	3	6
LUAD	NCAPG →	+0.557	+0.452	<.001	.002	3	6
GBM	NCAPH →	+0.542	+0.390	<.001	<.001	3	6
LSCC	NUFIP2_T87 →	+1.214	+0.970	<.001	<.001	3	6
LUAD	RACGAP1 →	+0.646	+0.481	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,446 associations by consensus.

SMS vs SMC2 — GBM

Explore this scatter interactively →