SMS

Across TCGA patient cohorts, SMS mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMS-associated genes across cancer lineages are FoxM1, Cyclin-E2, and INPP4B. Each is linked with SMS in more than 1 cancer types. Because this analysis shows association rather than direction, both SMS-to-partner and partner-to-SMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SMS-low versus SMS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMS→partner) and Y-score (partner→SMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.273	+2.584	.005	.001	3	2
UCEC	Cyclin-E2 →	+0.151	+1.678	.019	.023	3	2
UCEC	INPP4B →	-0.254	-2.807	.040	.003	3	1
UCEC	JNK2 →	+0.199	+2.009	.008	.017	3	1
UCEC	Ku80 →	+0.227	+1.884	.012	.030	3	1
UCEC	MEK1 →	+0.318	+2.807	.023	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FoxM1 by SMS expression — UCEC

Explore this box plot interactively →