SMR3B

Across TCGA patient cohorts, SMR3B mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SMR3B-associated genes across cancer lineages are CD4+ Tem and mv Endothelial cells. Each is linked with SMR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both SMR3B-to-partner and partner-to-SMR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tem grouped by SMR3B-low versus SMR3B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMR3B→partner) and Y-score (partner→SMR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD4+ Tem →	+0.029	+6.234	<.001	.026	3	1
SKCM	mv Endothelial cells →	-0.032	-2.453	.013	.020	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tem by SMR3B expression — BRCA

Explore this box plot interactively →