SMPX

Across TCGA patient cohorts, SMPX protein abundance is significantly associated with the RNA expression of many other genes, with 4,377 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SMPX-associated genes across cancer lineages are THBS4, CPXM2, and LDB3. Each is linked with SMPX in more than 3 cancer types. Because this analysis shows association rather than direction, both SMPX-to-partner and partner-to-SMPX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPX versus THBS4 in HNSC, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPX→partner) and Y-score (partner→SMPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THBS4 →	+1.615	+1.286	<.001	<.001	3	4
GBM	CPXM2 →	+1.237	+0.969	.006	.004	3	3
HNSC	LDB3 →	+1.584	+1.492	<.001	<.001	3	3
GBM	PLP1 →	+2.236	+0.772	<.001	<.001	3	3
COAD	RAMP1 →	+1.455	+0.572	<.001	.001	3	3
GBM	SLC7A14 →	+1.580	+1.113	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,377 associations by consensus.

SMPX vs THBS4 — HNSC

Explore this scatter interactively →