SMPX

Across TCGA patient cohorts, SMPX mutation is significantly associated with the RNA expression of many other genes, with 894 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPX-associated genes across cancer lineages are RN7SL240P, MIR7-2, and ANAPC15P2. Each is linked with SMPX in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPX-to-partner and partner-to-SMPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL240P grouped by SMPX-low versus SMPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPX→partner) and Y-score (partner→SMPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL240P →	+0.106	+3.579	<.001	.002	3	2
SKCM	MIR7-2 →	+0.287	+5.199	<.001	.003	3	2
SKCM	ANAPC15P2 →	+0.143	+4.765	.004	.003	3	2
UCEC	SMIM28 →	+0.356	+2.540	<.001	.002	3	1
UCEC	MIR4672 →	+0.457	+2.211	<.001	.007	3	1
UCEC	RN7SL237P →	+0.355	+2.496	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 894 associations by consensus.

RN7SL240P by SMPX expression — UCEC

Explore this box plot interactively →