SMPX

Across TCGA patient cohorts, SMPX mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPX-associated genes across cancer lineages are EGFR_pY1068, Acetyl-a-Tubulin-Lys40, and JNK2. Each is linked with SMPX in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPX-to-partner and partner-to-SMPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SMPX-low versus SMPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPX→partner) and Y-score (partner→SMPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.347	-3.584	.004	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.599	+2.459	.014	.020	3	1
UCEC	JNK2 →	+0.189	+2.817	.049	.036	3	1
UCEC	MAPK_pT202_Y204 →	-0.476	-3.000	.036	.036	3	1
UCEC	Notch1 →	+0.174	+2.820	.010	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.535	-3.000	.013	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by SMPX expression — UCEC

Explore this box plot interactively →