SMPDL3A

Across TCGA pan-cancer cohorts, SMPDL3A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SMPDL3A data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SMPDL3A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMPDL3A expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where SMPDL3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.306	0.903	.006	40	view →
PDAC	OS	Median	All	0.887	0.805	.003	19	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	13	view →
GBM	DFS	Median	All	0.783	0.659	.030	2	view →
LSCC	DFS	Quartile	All	0.647	0.854	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SMPDL3A–UCEC (OS)

Open the UCEC breakdown →