SMPDL3A

Across TCGA patient cohorts, SMPDL3A mutation is significantly associated with the RNA expression of many other genes, with 3,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPDL3A-associated genes across cancer lineages are NF1P10, RNA5SP413, and MIR4445. Each is linked with SMPDL3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPDL3A-to-partner and partner-to-SMPDL3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P10 grouped by SMPDL3A-low versus SMPDL3A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3A→partner) and Y-score (partner→SMPDL3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	NF1P10 →	+0.175	+5.569	<.001	.002	3	2
LUAD	RNA5SP413 →	+0.274	+7.930	<.001	.008	3	2
UCEC	MIR4445 →	+0.189	+4.571	<.001	.002	3	2
SKCM	CDRT15P3 →	+0.044	+4.563	.001	.004	3	2
SKCM	OR6C65 →	+0.036	+5.797	<.001	.001	3	2
SKCM	RBPJP6 →	+0.025	+4.970	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,236 associations by consensus.

NF1P10 by SMPDL3A expression — CESC

Explore this box plot interactively →