SMPDL3A

Across TCGA patient cohorts, SMPDL3A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPDL3A-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and JNK2. Each is linked with SMPDL3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPDL3A-to-partner and partner-to-SMPDL3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SMPDL3A-low versus SMPDL3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3A→partner) and Y-score (partner→SMPDL3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.269	-2.321	.021	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-2.571	.008	.011	3	1
UCEC	JNK2 →	+0.279	+2.584	.002	.011	3	1
UCEC	Ku80 →	+0.245	+1.887	.026	.031	3	1
UCEC	Notch1 →	+0.205	+3.013	.001	.018	3	1
UCEC	P-Cadherin →	-0.152	-3.159	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by SMPDL3A expression — UCEC

Explore this box plot interactively →