SMPDL3A

Across TCGA cell cohorts, SMPDL3A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,317 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMPDL3A-associated GO terms across cancer lineages are Negative regulation of NK T cell activation, Endosome transport via multivesicular body sorting pathway, and Glycerophospholipid metabolic process. Each is linked with SMPDL3A in more than 9 cancer types. Because this analysis shows association rather than direction, both SMPDL3A-to-partner and partner-to-SMPDL3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of NK T cell activation grouped by SMPDL3A-low versus SMPDL3A-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPDL3A→partner) and Y-score (partner→SMPDL3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of NK T cell activation →	+0.372	+1.412	.006	<.001	3	10
SOFT_TISSUE	Endosome transport via multivesicular body sorting pathway →	+0.055	+1.127	<.001	<.001	3	10
URINARY_TRACT	Glycerophospholipid metabolic process →	+0.043	+1.250	<.001	<.001	3	10
CNS	Endosome organization →	+0.043	+0.842	<.001	<.001	3	9
KIDNEY	Basophil activation →	-0.197	-1.925	<.001	<.001	3	9
OVARY	Sensory perception of touch →	+0.231	+1.428	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,317 associations by consensus.

Negative regulation of NK T cell activation by SMPDL3A expression — BLOOD_Lymphoma

Explore this box plot interactively →