Across TCGA patient cohorts, SMPD5 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,441 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMPD5-associated proteins across cancer lineages are OPLAH_T151, MLPH, and OPLAH. Each is linked with SMPD5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMPD5-to-partner and partner-to-SMPD5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD5→partner) and Y-score (partner→SMPD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OPLAH_T151 →	+0.931	+0.610	<.001	<.001	2	6
LUAD	MLPH →	-0.665	-0.368	<.001	.006	3	4
GBM	OPLAH →	+0.644	+0.697	<.001	.001	3	4
COAD	COPZ1 →	-0.208	-0.223	.001	.005	3	3
LSCC	ZNF318_S709 →	+0.687	+1.011	<.001	<.001	3	3
HNSC	ZNF318_S81 →	+0.461	+0.508	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,441 associations by consensus.

Exploration

SMPD5 survival (RNA) · tumor vs normal (RNA) · all SMPD5 data types