Across TCGA pan-cancer cohorts, SMPD4P1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SMPD4P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SMPD4P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SMPD4P1 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

HNSC, LUSC, and LUAD are the cancer types where SMPD4P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SMPD4P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.809	<.001	12	view →
LUSC	All	All	+0.497	<.001	6	view →
LUAD	All	III,IV	−0.076	<.001	4	view →
LIHC	All	All	+0.111	.031	1	view →
THCA	All	All	−0.020	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SMPD4P1 RNA expression & survival · all SMPD4P1 data types