SMPD4BP

Across TCGA patient cohorts, SMPD4BP mutation is significantly associated with the RNA expression of many other genes, with 3,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD4BP-associated genes across cancer lineages are HROB, CDCA8, and CALM3. Each is linked with SMPD4BP in more than 3 cancer types. Because this analysis shows association rather than direction, both SMPD4BP-to-partner and partner-to-SMPD4BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HROB grouped by SMPD4BP-low versus SMPD4BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD4BP→partner) and Y-score (partner→SMPD4BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HROB →	+0.466	+2.332	.001	<.001	3	4
COAD	CDCA8 →	+0.668	+3.486	<.001	.002	3	4
COAD	CALM3 →	+0.491	+3.237	.002	.008	3	3
COAD	SPC24 →	+0.526	+3.513	.003	.002	3	3
UCEC	MRPS18C →	+0.376	+3.130	<.001	<.001	3	3
UCEC	SMIM12 →	+0.277	+1.947	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,161 associations by consensus.

HROB by SMPD4BP expression — UCEC

Explore this box plot interactively →