SMPD4BP

Across TCGA patient cohorts, SMPD4BP mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD4BP-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and FoxM1. Each is linked with SMPD4BP in more than 2 cancer types. Because this analysis shows association rather than direction, both SMPD4BP-to-partner and partner-to-SMPD4BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SMPD4BP-low versus SMPD4BP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD4BP→partner) and Y-score (partner→SMPD4BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.321	+2.700	<.001	.005	3	3
UCEC	A-Raf_pS299 →	-0.128	-1.807	.001	.004	3	2
UCEC	FoxM1 →	+0.291	+2.523	<.001	<.001	3	2
UCEC	Notch1 →	+0.203	+2.100	<.001	.002	3	2
COAD	PCNA →	+0.352	+2.820	.003	.035	3	2
UCEC	PDCD4 →	-0.588	-2.807	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

4E-BP1 by SMPD4BP expression — UCEC

Explore this box plot interactively →