SMPD4

Across TCGA pan-cancer cohorts, SMPD4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SMPD4 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SMPD4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SMPD4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where SMPD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.114	1.000	.017	24	view →
LSCC	DFS	Median	II,III,IV	0.855	0.538	.008	16	view →
CCRCC	DFS	Tertile	IV	0.108	0.758	.024	10	view →
UCEC	DFS	Quartile	All	0.768	0.963	.044	4	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
PDAC	OS	Median	III,IV	0.918	0.594	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SMPD4–HNSC (OS)

Open the HNSC breakdown →