SMPD4

Across TCGA patient cohorts, SMPD4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SMPD4-associated genes across cancer lineages are Cyclin-E2, 14-3-3_epsilon, and GAPDH. Each is linked with SMPD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SMPD4-to-partner and partner-to-SMPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SMPD4-low versus SMPD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD4→partner) and Y-score (partner→SMPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.114	+1.161	.023	.032	3	4
COAD	14-3-3_epsilon →	+0.160	+3.017	.005	.017	3	3
COAD	GAPDH →	+0.557	+3.467	.014	.002	3	3
COAD	MEK1_p_S217_S221 →	+0.290	+2.330	.036	.020	3	2
COAD	PCNA →	+0.431	+3.012	<.001	.018	3	2
COAD	Stathmin →	+0.178	+2.330	.009	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Cyclin-E2 by SMPD4 expression — UCEC

Explore this box plot interactively →