SMPD4

Across TCGA cell cohorts, SMPD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,147 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SMPD4-associated GO terms across cancer lineages are Positive regulation of mitotic cytokinesis, DNA integrity checkpoint signaling, and Positive regulation of cell cycle. Each is linked with SMPD4 in more than 18 cancer types. Because this analysis shows association rather than direction, both SMPD4-to-partner and partner-to-SMPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cytokinesis grouped by SMPD4-low versus SMPD4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD4→partner) and Y-score (partner→SMPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of mitotic cytokinesis →	+0.160	+1.003	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.105	+0.969	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle →	+0.080	+1.115	<.001	<.001	3	17
SOFT_TISSUE	Spindle localization →	+0.135	+0.899	<.001	<.001	3	17
BONE	DNA replication →	+0.124	+0.982	.005	.001	3	17
BONE	RNA export from nucleus →	+0.135	+0.839	<.001	.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,147 associations by consensus.

Positive regulation of mitotic cytokinesis by SMPD4 expression — BONE

Explore this box plot interactively →