SMPD4

Across TCGA cell cohorts, SMPD4 mutation is significantly associated with the RNA expression of many other genes, with 1,359 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMPD4-associated genes across cancer lineages are C16orf90, SLCO1C1, and GALR3. Each is linked with SMPD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPD4-to-partner and partner-to-SMPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf90 grouped by SMPD4-low versus SMPD4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD4→partner) and Y-score (partner→SMPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C16orf90 →	+0.024	+4.315	.005	.006	3	2
BLOOD_Leukemia	SLCO1C1 →	+0.076	+3.705	<.001	.007	3	2
LARGE_INTESTINE	GALR3 →	+0.096	+2.695	<.001	<.001	3	2
BLOOD_Lymphoma	TAS2R7 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Leukemia	CST9L →	+0.411	+4.269	<.001	.002	3	1
BLOOD_Leukemia	DEFB126 →	+0.025	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,359 associations by consensus.

C16orf90 by SMPD4 expression — CNS

Explore this box plot interactively →