SMPD2

Across TCGA patient cohorts, SMPD2 mutation is significantly associated with the RNA expression of many other genes, with 635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD2-associated genes across cancer lineages are LINC01047, OR2AI1P, and RNU6-120P. Each is linked with SMPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPD2-to-partner and partner-to-SMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01047 grouped by SMPD2-low versus SMPD2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD2→partner) and Y-score (partner→SMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01047 →	+0.056	+5.306	<.001	.006	3	2
CESC	OR2AI1P →	+0.047	+5.669	<.001	.003	3	2
UCEC	RNU6-120P →	+0.254	+2.901	<.001	.009	3	2
COAD	LINC00351 →	+0.254	+4.484	.001	.002	3	2
UCEC	IGHV3OR16-8 →	+0.645	+2.950	.004	<.001	3	1
UCEC	TBC1D8-AS1 →	-0.412	-3.419	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 635 associations by consensus.

LINC01047 by SMPD2 expression — CESC

Explore this box plot interactively →