SMPD2

Across TCGA cell cohorts, SMPD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,422 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SMPD2-associated GO terms across cancer lineages are Quinone biosynthetic process, Ubiquinone biosynthetic process, and Ubiquinone metabolic process. Each is linked with SMPD2 in more than 13 cancer types. Because this analysis shows association rather than direction, both SMPD2-to-partner and partner-to-SMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Quinone biosynthetic process grouped by SMPD2-low versus SMPD2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD2→partner) and Y-score (partner→SMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Quinone biosynthetic process →	+0.086	+0.581	.004	.001	2	14
OVARY	Ubiquinone biosynthetic process →	+0.086	+0.581	.004	.001	2	14
LARGE_INTESTINE	Ubiquinone metabolic process →	+0.080	+0.517	<.001	<.001	3	12
BREAST	Quinone metabolic process →	+0.091	+0.865	<.001	<.001	3	11
LUNG_NSCLC_LUAD	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.064	+0.618	<.001	.006	3	10
BREAST	Ketone biosynthetic process →	+0.101	+0.938	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,422 associations by consensus.

Quinone biosynthetic process by SMPD2 expression — OVARY

Explore this box plot interactively →