SMPD1

Across TCGA patient cohorts, SMPD1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,796 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SMPD1-associated proteins across cancer lineages are HEATR1, PTMA, and TRIM33_S862. Each is linked with SMPD1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SMPD1-to-partner and partner-to-SMPD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPD1 versus HEATR1 in LSCC, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD1→partner) and Y-score (partner→SMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HEATR1 →	-0.302	-0.523	.007	<.001	3	7
OV	PTMA →	-0.958	-0.859	.001	.001	3	6
BRCA	TRIM33_S862 →	-0.765	-0.697	<.001	<.001	3	6
BRCA	VRK1 →	-0.473	-0.714	<.001	<.001	3	6
OV	WDR43 →	-0.287	-0.685	<.001	.002	3	6
BRCA	WDR43_S77 →	-0.765	-0.617	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,796 associations by consensus.

SMPD1 vs HEATR1 — LSCC

Explore this scatter interactively →