SMPD1

Across TCGA patient cohorts, SMPD1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,097 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SMPD1-associated genes across cancer lineages are SNED1, TMEM9B, and SORCS2. Each is linked with SMPD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SMPD1-to-partner and partner-to-SMPD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SMPD1 versus SNED1 in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD1→partner) and Y-score (partner→SMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNED1 →	+0.806	+0.317	<.001	<.001	3	5
LUAD	TMEM9B →	+0.346	+0.266	<.001	<.001	3	5
LUAD	SORCS2 →	+1.049	+0.302	.003	<.001	3	5
OV	ZCCHC24 →	+1.078	+0.507	.005	.005	2	6
BRCA	VSTM4 →	+0.773	+0.354	<.001	<.001	3	5
UCEC	TXNDC15 →	+0.469	+0.223	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,097 associations by consensus.

SMPD1 vs SNED1 — BRCA

Explore this scatter interactively →