SMPD1

Across TCGA patient cohorts, SMPD1 mutation is significantly associated with the RNA expression of many other genes, with 3,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD1-associated genes across cancer lineages are PSAT1P4, SLC25A4, and BUB3. Each is linked with SMPD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMPD1-to-partner and partner-to-SMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by SMPD1-low versus SMPD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD1→partner) and Y-score (partner→SMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSAT1P4 →	+0.229	+2.463	<.001	.009	3	3
COAD	SLC25A4 →	+0.604	+3.223	<.001	.009	3	2
UCEC	BUB3 →	+0.453	+1.840	<.001	.006	3	2
UCEC	DONSON →	+0.525	+2.095	<.001	.003	3	2
UCEC	ZBTB8A →	+0.463	+2.705	<.001	<.001	3	2
UCEC	GFI1 →	+0.515	+2.021	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,000 associations by consensus.

PSAT1P4 by SMPD1 expression — COAD

Explore this box plot interactively →