SMPD1

Across TCGA patient cohorts, SMPD1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SMPD1-associated genes across cancer lineages are mTOR_pS2448, eIF4E, and MEK1. Each is linked with SMPD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SMPD1-to-partner and partner-to-SMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SMPD1-low versus SMPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD1→partner) and Y-score (partner→SMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.159	-2.687	.002	.005	3	3
UCEC	eIF4E →	+0.169	+3.700	.023	.001	3	2
UCEC	MEK1 →	+0.490	+2.874	<.001	<.001	3	2
UCEC	PCNA →	+0.186	+1.662	.014	.011	3	2
UCEC	PKC-delta_pS664 →	-0.084	-1.662	.046	.011	3	2
UCEC	STAT3_pY705 →	-0.335	-1.668	<.001	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

mTOR_pS2448 by SMPD1 expression — UCEC

Explore this box plot interactively →