SMPD1

Across TCGA cell cohorts, SMPD1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMPD1-associated genes across cancer lineages are SMIM28, COX4I2, and MBD3L2. Each is linked with SMPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMPD1-to-partner and partner-to-SMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM28 grouped by SMPD1-low versus SMPD1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMPD1→partner) and Y-score (partner→SMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SMIM28 →	+0.023	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	MBD3L2 →	+0.151	+5.228	<.001	.005	3	1
LUNG_SCLC	GRIFIN →	+0.117	+5.029	<.001	.006	3	1
BLOOD_Lymphoma	LUZP4 →	+0.108	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	BMP15 →	+0.021	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SMIM28 by SMPD1 expression — BLOOD_Myeloma

Explore this box plot interactively →